Donor buffy-coat infusion and chemotherapy for leukemia in relapse after marrow transplantation.
نویسندگان
چکیده
A patient relapsing with blastic lymphoid transformation of chronic myeloid leukemia after bone marrow transplantation received donor buffy-coat infusion. Low-dose chemotherapy was added because of a rapid WBC increase. Complete hematologic and cytogenetic remission was obtained. The patient remained in complete hematologic and cytogenetic remission for four months until he died in an accident. Two patients with acute leukemia failed to respond to a similar treatment.
منابع مشابه
Donor Leukocyte Infusions for Chronic Myeloid Leukemia in Relapse after Allogeneic Bone Marrow Transplantation
Allogeneic bone marrow transplantation (BMT) is the only curative therapy for chronic myeloid leukemia (CML), but relapse occurs in approximately 10% of patients transplanted in chronic phase with non T-cell-depleted marrow.’” The risk of relapse is substantially greater if T-cell depletion of donor marrow is used as prophylaxis against graft-versus-host disease (GVHD), when relapse rates of 50...
متن کاملDonor Leukocyte Infusions for Chronic Myeloid Leukemia in Relapse after Allogeneic Bone Marrow Transplantation
Allogeneic bone marrow transplantation (BMT) is the only curative therapy for chronic myeloid leukemia (CML), but relapse occurs in approximately 10% of patients transplanted in chronic phase with non T-cell-depleted marrow.’” The risk of relapse is substantially greater if T-cell depletion of donor marrow is used as prophylaxis against graft-versus-host disease (GVHD), when relapse rates of 50...
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Three patients with hematologic relapse after bone marrow transplantation for chronic myelogenous leukemia were treated with interferon alpha and transfusion of viable donor buffy coat. All had complete hematologic and cytogenetic remission, which persisted 32 to 91 weeks after treatment. In two patients graft-versus-host disease developed and was treated by immunosuppression. These results are...
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In order to obtain an additional graft versus leukemia effect (GVL) and rapid engraftment, donor leukocyte infusion (DLI) was added to unseparated, sex-mismatched allogeneic bone marrow transplantation in two male patients (age 21, 26) affected by high risk hematological malignancies (refractory T-ALL, refractory B-LBL in leukemic phase). Graft versus host disease (GVHD) prophylaxis consisted o...
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ورودعنوان ژورنال:
- Haematologica
دوره 80 4 شماره
صفحات -
تاریخ انتشار 1995